The worldwide incidence of autism is 1 out of every 68 births. Stem cell therapy is now available to all patients with autism or autism spectrum disorder (ASD) around the world. Here at Cedar Stem Cell Institute in Columbus, Ohio, we offer treatment options to patients 16 years or older.
What is autism?
Autism or Autism spectrum disorder (ASD) refers to a group of complex neurodevelopment disorders characterized by repetitive and characteristic patterns of behavior and difficulties with social communication and interaction. The symptoms are present from early childhood and affect daily functioning.
The term “spectrum” refers to the wide range of symptoms, skills, and levels of disability in functioning that can occur in people with ASD. Some children and adults with ASD are fully able to perform all activities of daily living while others require substantial support to perform basic activities. The DSM classification of Disorders (DSM-5, published in 2013) defines ASD to include Asperger syndrome, childhood disintegrative disorder, and pervasive developmental disorders not otherwise specified (PDD-NOS) as part of ASD rather than as separate disorders. A diagnosis of ASD includes an assessment of intellectual disability and language impairment.
ASD occurs in every racial and ethnic group, and across all socioeconomic levels. However, boys are significantly more likely to develop ASD than girls. The latest analysis from the Centers for Disease Control (CDC) estimates that 1 in 68 children have ASD. At present, there is no cure, only palliative support and behavioral therapy. In some cases medicine is given to assist with attention deficit and seizures. However, stem cells and regenerative medicine give us some early signs of hope.
How can stem cell therapy treat autism?
Through intrathecal injection–injecting stem cells directly into the spinal canal–these stem cells are showing to improve neurological function. The cells used are called mesenchymal stem cells (MSCs). Mesenchymal stem cells (MSCs) are multipotent cells that can differentiate into a variety of cells such as cartilage cells, muscle cells, fat cells, and even bone cells. One study of several patients showed about 88% incidence of neurological improvement after intrathecal injection of mesenchymal stem cells¹.
At Cedar Stem Cell Institute in Columbus, Ohio, we offer treatment options for autism, including intrathecal mesenchymal stem cell therapy with and without platelet-rich plasma (PRP) .
¹ Sharma A, Gokulchandran N, Chopra G,et al, Cell Transplant.2012;21 Suppl 1:S79-90.
Sharma A, Badhe P, Gokulchandran N, Kulkarni P, Mishra P, Shetty A, Sane H. An Improved Case of Autism as Revealed by PET CT Scan in Patient Transplanted with Autologous Bone Marrow Derived Mononuclear Cells.J Stem Cell Res Ther. 2013;3:139.
Siniscalco D, et al 2013: Perspectives on the use of stem cells for autism treatment. Stem Cells Int 2013;262438
Siniscalco D et al 2014: World J Stem Cells 2014 Apr 26; 6(2): 173-178. Mescenchymal stem cells in treating autism: Novel insights