Exosomes as New Type of Regenerative Medicine

Exosome

Exosomes are vesicular bodies with a bilayer membrane which are released from the cell membrane of cells in order to communicate with other cells in the body (intercellular communication). These vesicular bodies are small packets of bioactive substances including proteins, lipids, microRNA, RNA and DNA. Exosomes can be derived from mesenchymal stem cells but they can be released by many different types of cells. Exosomes play a role in CNS diseases such as stroke, Alzheimer’s Disease, Parkinson’s disease, ALS and Huntington’s disease.

Exosomes in the nervous system have a variety of functions, which includes maintaning the myelin sheath, promoting nerve axon regeneration, facilitating neuronal firing and eliminating waste. Furthermore, being so exceedingly small exosomes have the distinct advantage of being able to penetrate the blood brain barrier.

There is much animal research that exosomes are helpful but much fewer studies on human patients. However, in recent times there has been an explosion of interest in exosomes in people and Cedar Stem Cell Institute is interested in conducting some clinical trials using exosomes for various neurological and musculoskeletal diseases. Exosomes are also being studied at Massachusetts General Hospital at Harvard and Yale and result getting published in highly respected journals such as New England Journal of Medicine, Stroke and Journal of Neurosurgery. Please contact Cedar Stem Cell Institute if you are interested in learning more about exosome treatments.

Watch Neurosurgeon Joseph Shehadi MD give an overview of Exosomes. The history, the uses, and everything else you need to know about this nanoscience.


Neurosurgery Associates

 

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